For a more detailed review about the medical treatment and management of SCAD please refer toSpontaneous coronary artery dissection – A review.byYip A., Saw J., inCardiovasc Diagn Ther. 2015 Feb;5(1):37-48.
The long-term prognosis for SCAD survivors aftertheir initial SCAD presentation is good. RecurrentSCAD events, however, are frequent and these patients must be followedclosely. Conservative medical management for stable patientswith resolved ischemia is typical. Revascularization via percutaneous coronary intervention (PCI) or coronary artery bypass graft surgery (CABG) may be necessary for a small percentage ofpatients.
The following figure is a flow-chart providing a process for managing the medical treatment of SCAD patients.
Figure 1: Management algorithm including revascularization for acute presentation of SCAD[1]
SCAD, spontaneous coronary artery dissection; PCI, percutaneous coronary intervention; CABG, coronary artery bypass grafting
Medical Therapy
Standard acute coronary syndrome (ACS) pharmaceutical agents may or may not be beneficial for SCAD. In addition, the use of antiplatelet therapy in the treatment of SCAD is also unclear for patients not treated with stents.
A percentage of SCAD events involve intimal tears that are prothrombotic and would likely benefit from antiplatelet therapy. Therefore, we typically administer aspirin and clopidogrel for acute SCAD patients and follow-up with clopidogrel for 1 year and aspirin for life.
However, the use of new P2Y12 antagonists (prasugrel and ticagrelor) is unclear and GPIIb/IIIa inhibitors for acute SCAD management have also not been evaluated. Due to their greater potency, higher bleeding risk, and potential risk of extending dissections, they are not normally recommended for SCAD treatment.
Anticoagulation treatment for SCAD is controversial. While there is a risk of extending dissections this is balanced by thepotential to resolve overlying thrombus andimprove true lumen patency. Although ACS patients presenting at hospital are typically treated with heparin agents, it is recommended this be discontinued once SCAD isdetected on angiography to avoid extension of intramural hematoma (IMH).
Medical management of SCAD deviates from standard ACS therapy. In particular, thrombolytic therapy should be avoided for patients with SCAD. Therefore, early coronary angiography to establish SCAD is important. If, however, angiography is not available, then thrombolysis should not be withheld forST-elevation MI patients because the overall frequency ofthrombotic occlusion is much higher than SCAD. While therehave been anecdotal reports of successful thrombolysis withSCAD, these reports are limited and most datasuggest negative effects with thrombolysis for SCAD.
Beta-blockers offer benefits in aortic dissection by reducing arterial wall shear stress.Extrapolating these benefits,we routinely administer beta-blockers for SCAD, both acutely and long-term.
While nitroglycerin may be useful inalleviating ischemic symptomsduring acute SCAD presentation, it is not routinely usedlong-term.
Angiotensin-converting enzyme inhibitors areadministered when there is significant post-MI LVdysfunction (ejection fraction ≤40% and class 1indication).
Statin use for non-atheroscleroticSCAD has not been studied. We would administerstatins only to patients with preexisting dyslipidemia.
Revascularization
The choice to revascularize a dissected arterydepends on both the affected coronary anatomy and the patient’s clinical status. Conservative treatmentis preferred for most stable patients without ongoing pain.However, patients with ongoing chest pain, ischemia, ST elevation,or hemodynamic instability should undergo PCI, especiallywhen the dissection affects major arteries with sizablemyocardial jeopardy.
Emergency CABG should be considered for patients where the dissection involves the left main. However, dissections of proximal segments of left anterior descending(LAD), circumflex or right coronary artery should beintervened percutaneously if feasible.
Stenting may not be practical where the dissected artery segment is distal, of small calibre,or when the dissection is extensive. Attempts at revascularization of dissected coronary arteries may be very challenging and can often result in poor outcomes.Initially it may be challenging to advance the coronaryguidewire into the distal true lumen. Additionally, the IMH of a dissection may extend antegradely orretrogradely with angioplasty, further impeding arterialblood flow and extending the dissection. Distal coronary arteries with dissections may be too smallto implant stents. For dissected arteries that are larger,the dissections may also be longer and require long stents, leading to increased risk of restenosis. Furthermore,IMH resorb and heal over time, and may result in latestrut malapposition, increasing the risk of very late stentthrombosis especially after cessation of dual anti-platelettherapy. Lastly, the natural history of the dissected segmentsis such that the vast majority heals spontaneously, andpatients appear to have good long-term outcome if theysurvive their initial event.Werecommend reserving PCI for patients with ongoing chestpain and ischemia when the lesion is amenable to stenting,and to consider CABG for extensive dissections involvingthe left main.
If PCI is attempted, there are strategies that mayimprove outcome. If the lesion is relatively focal, werecommend selecting longer stents that would provideadequate coverage for both edges of the lesion (at least5-10 mm longer proximally and distally). This attemptsto accommodate extension of the IMH proximally anddistally when compressed by the stent. We recommendOCT or IVUS to ensure adequate stent coverage and wallapposition. For longer lesions, a multistep approach ofstenting the distal edge, followed by the proximal edge, andthen stenting the middle of the dissection, may be useful inpreventing IMH propagation. The use of bioresorbablestents also has theoretical benefits of avoiding late stentmalapposition following resorption of IMH.
There is no consensus as to repeat imaging after SCAD,irrespective of revascularization strategies. Because asignificant proportion of patients have recurrent chest painsafter their initial event, we find it useful to repeat coronaryangiography several weeks later to investigate potentialischemic causes of pain, and to assess arterial healing.
References
1. Saw J, Aymong E, Buller CE, Starovoytov A, Ricci D, Robinson S, Vuurmans T, Gao M, Humphries K, Mancini GBJ. Spontaneous Coronary Artery Dissection: Association with Predisposing Arteriopathies and Precipitating Stressors, and Cardiovascular Outcomes. Circ Cardiovasc Interv 2014;7(5):645-55.
DISCLAIMER: This webpage presents information regarding what we have learnt from our SCAD cohort.
Our suggested management may or may not apply to individual patients presenting with SCAD.
Patients should contact their health care professionals for specific individual management of their condition.
